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Title   제한단편길이 다형성 ( RFLPs ) 을 이용한 포상기태의 유전학적 분류 ( Genetic Classification of Hydatidiform Mole Using Restriciton Fragment Length Polymorphisms ( RFLPs ) )
Publicationinfo   1993 Jan; 025(04): 556-563.
Key_word   Hydatidiform mole, RFLPs
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Abstract   A wide-spectrum initiation model was investigated in female N: GP(S) mice. Sequential treatments with benzo(a)pyrene (BP), dimethylnitrosamine(DMN) dibutylnitrosamine(DBN), with or without N- methylnitrosourea(MNU), resulted in tu.mor formation in the lungs in 84.2-90.0% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were mainly adenomas and 4 cases showed carcinoma in adenoma. The mean number of adenoma was 13.2-16.2 per mouse. MNU combination had no additive effect on the lung tumor incidence, but significantly increased the lung tumor multiplicity. The carcinogen-treated animals showed cytomegaly of hepatocytes and this was more marked in MNU combined group. These results showed that a wide-spectrum initiation model was not established in this mouse system. Further study with a change in mouse strain or in combination of carcinogen, or increment of carcinogen dose would be necessary.
저 자   송종철(Jong Chul Song),백은정(Eun Jeong Baik),손우익(Woo Ik Son),유기성(Ki Sung Ryu),이준모(Joon Mo Lee),정재근(Jae Keun Jung),김승조(Seung Jo Kim),이헌영(Hun Young Lee)